U.S. stock markets opened in negative territory on Wednesday, with major indices posting early declines. The Nasdaq Composite fell 0.53%, while the Dow Jones Industrial Average dropped 0.35% and the S&P 500 slipped 0.28%. The broad-based selling pressure at the open saw technology stocks lead the downturn, as reflected in the Nasdaq's steeper decline compared to blue-chip and broader market benchmarks.