Dan Perkins stated that using intermediaries is unavoidable for managing significant assets in decentralized finance following the Ledger hack. He emphasized that while DeFi offers an incredible vision, holding large amounts of capital directly in the ecosystem remains difficult when users are exposed to security vulnerabilities. The comments highlight the ongoing tension between decentralization ideals and practical security needs for institutional-scale capital. Perkins argues that despite the benefits of DeFi, vulnerability risks currently necessitate trusted third parties for substantial asset custody.