Andreessen Horowitz rebranded its crypto investment arm from a16z crypto to a16z Frontier on October 22, expanding the new fund's scope from exclusively crypto startups to broader frontier technologies including AI, robotics, and biomedicine. The $2.2 billion fifth fund, closed just five months ago in May with explicit commitments to remain crypto-only, is now co-led by Chris Dixon, Marc Andreessen, Ben Horowitz, Eddy Lazzarin, and Guy Wuollet across these wider categories. The firm stated it will continue investing in cryptocurrencies and advocating for sound regulation, positioning blockchain as critical infrastructure for the AI era through stablecoins, programmable financial services, and machine-to-machine transactions. Recent portfolio moves already reflected this shift: a16z led a $33 million seed round for computing power company Ornn in June and invested in prediction market platform Kalshi alongside Sequoia Capital in October 2025. a16z's pivot mirrors similar expansions by Paradigm, which closed a $1.2 billion fund in July covering crypto, AI, robotics, and space defense, and Haun Ventures, which raised $1 billion in May focused on financial infrastructure and the agent economy. No disclosure has been made regarding capital allocation proportions between crypto and non-crypto investments or any new fundraising amounts.