Wells Fargo has introduced Bitcoin-backed loans for its institutional and wealth clients, accepting Bitcoin or spot Bitcoin ETFs as collateral. This move aligns with recent Basel III reforms and regulatory updates, marking a significant shift in the bank's approach to cryptocurrency. The initiative follows similar expansions by major U.S. banks such as JPMorgan, Citi, and Schwab, which have collectively issued approximately $50 billion in new credit lines since September 2025. This development highlights the growing institutional participation in crypto markets, a trend noted by Michael Saylor of MicroStrategy, as banks transition from cautious observation to active engagement.