Sei (SEI) is gaining attention with a 76% increase in wallet count, reaching 8.3 million, and a DeFi volume of $9.88 billion by late September. SUI, with a market cap of $1.7 billion, faces challenges for 5x growth but could achieve 2-3x returns. Hyperliquid (HYPE) reported $320 billion in trading volume and $86.6 million in protocol revenue, though its valuation may limit upside potential. Avalanche (AVAX), with a $12 billion market cap, has growth potential but is constrained by its size. Solana, valued at $85 billion, is unlikely to see 5x growth due to its established status. Analysts suggest that at least one of these tokens could approach 5x growth, especially given historical gains during "Uptober."