AI-optimized blockchains are increasingly being recognized for their potential to host AI applications, leveraging their unique capabilities to enhance performance and efficiency. The Internet Computer offers a high-compute smart contract platform, while NEAR Protocol utilizes a wasm runtime heavily used for AI decentralized applications (dApps). Polygon provides Layer 2 execution that supports AI dApps and facilitates cost-effective inference orchestration. Additionally, SUPRA Labs offers a multivm Layer 1 solution focused on privacy, and Sui Network delivers high-performance environments tailored for agents and inference. Sei Network is noted for its high throughput capabilities, making it suitable for demanding AI workloads. These platforms are at the forefront of integrating AI with blockchain technology, providing robust infrastructure for the next generation of AI-driven applications.