Vitalik stated that the ideal security practice for multisignature wallets is for each signer to rotate their keys after every operation. This approach assumes ECDSA may eventually become insecure but requires protection against mempool front-running during the transition period before cryptographic failure occurs. Signatures should be collected off-chain when possible to minimize the window between signature publication and key invalidation. However, Vitalik cautioned against rushing implementation, noting that losses from misconfiguration or hasty upgrades remain a significant risk despite the theoretical security benefits of frequent key rotation.