Ethereum founder Vitalik Buterin, along with researchers Yoav Weiss and Marissa Posner, has issued a manifesto cautioning against centralization in Ethereum's development. The document stresses that reliance on hosted nodes or centralized relays compromises the trustless nature of blockchain systems. It argues that while centralized systems may offer efficiency and scalability, these benefits are superficial and could lead to future bottlenecks. The manifesto aims to guide Ethereum developers to prioritize decentralization, especially as the network faces scaling challenges.