The U.S. stock markets opened lower on October 14, with major indices experiencing significant declines. The Dow Jones Industrial Average fell by 361.69 points, or 0.79%, to 45,705.89. Meanwhile, the S&P 500 decreased by 64.93 points, or 0.98%, reaching 6,589.76. The Nasdaq Composite also saw a drop, losing 322.48 points, or 1.42%, to settle at 22,372.12.