US crypto-related stocks experienced significant declines as major stock indices opened lower on December 1. Notable drops included Bitmine (BMNR), which fell 7.91%, and American Bitcoin (ABTC), which dropped 8.49%. Other significant declines were seen in SharpLink Gaming (SBET) at 8.19%, Bullish (BLSH) at 6.67%, and ALT5 Sigma (ALTS) at 6.68%. Coinbase (COIN) and MicroStrategy (MSTR) also saw declines of 3.09% and 6.15%, respectively.