The United States has advanced to second place in the 2025 Chainalysis Global Crypto Adoption Index, propelled by increased institutional activity and regulatory clarity. India tops the index, demonstrating robust retail and institutional engagement. The U.S. experienced significant growth due to regulatory developments and the introduction of spot Bitcoin ETFs, which attracted $442 million in net inflows. Large transfers exceeding $1 million have been pivotal, with hedge funds, custodians, and banks expanding their operations. The Asia-Pacific region recorded the fastest growth in crypto volume, led by India, Vietnam, and Pakistan, while North America maintained its leadership in absolute volume. The report underscores the integration of cryptocurrency into finance, with high-income countries developing institutional frameworks and low-income countries utilizing crypto for remittances and dollar transactions.