A recent analysis of U.S. government data reveals that popular startup methodologies, such as Lean Startup, Customer Development, and Business Model Canvas, have not statistically improved startup survival rates over the past 30 years. Despite widespread adoption and millions of book sales, these methodologies have not led to a significant increase in the longevity of startups, including those in the crypto and Web3 sectors. The study suggests that the lack of differentiation among startups following the same methodologies may contribute to their failure. As these approaches become ubiquitous, they lose their competitive edge, resulting in similar business models that struggle to stand out. The findings challenge the effectiveness of current entrepreneurial frameworks and call for a reevaluation of what constitutes a science of entrepreneurship.