A Polymarket user, identified as @anoin123, has incurred a significant loss of $6.74 million following the U.S. announcement of sanctions against Iran. The user had previously accumulated over $2 million in profits by betting that the U.S. would not strike Iran, typically purchasing bets when market probabilities were between 70% and 90% for low-risk returns. The recent sanctions announcement led to a daily loss that erased all previous gains, resulting in a total account loss of $4.49 million.