An extensive on-chain analysis of 95 million transactions on Polymarket has identified six core profit strategies for 2025. These strategies include information arbitrage, cross-platform arbitrage, high-probability bond strategies, liquidity provision, domain specialization, and speed trading. Despite the vast number of transactions, only 0.51% of wallets achieved profits exceeding $1,000, highlighting the competitive nature of the market. The analysis, covering data from April 2024 to December 2025, underscores the importance of exploiting market inefficiencies, maintaining rigorous risk control, and leveraging domain expertise. The study utilized data from Polymarket Analytics, Dune, and Chainalysis to provide insights into successful trading tactics on the platform.