Major Layer 1 and Layer 2 crypto tokens experienced significant declines in 2025, with monthly active users falling by 25.15% across leading networks. Solana was notably affected, losing nearly 60% of its user base, while BNB Chain saw its user count nearly triple. Despite an increase in developer activity, most Layer 1 tokens ended the year with losses. Revenue shifted towards stablecoin and derivatives sectors, highlighting tokenomics issues and weak market positioning as contributing factors. Underperforming protocols continue to face selling pressure.