Framework Ventures co-founder Vance Spencer anticipates a significant shift in the cryptocurrency industry, moving away from meme coins, NFTs, and low-circulation high FDV narratives. Spencer forecasts a notable reduction in token issuance by 2026, with market focus increasingly on mainstream assets like Bitcoin and Ethereum. Institutional funds are expected to continue flowing into DeFi blue-chip projects with value capture mechanisms. Future industry directions are likely to emphasize stablecoins, real-world assets (RWA), lending and capital markets, and asset management.