Fannie Mae, the U.S. government-sponsored enterprise, will begin accepting cryptocurrency-backed mortgages, marking a significant shift in its mortgage acquisition strategy. This move allows borrowers to use digital assets as collateral, potentially broadening access to home financing for cryptocurrency holders. Fannie Mae, established in 1938, plays a crucial role in enhancing liquidity in the housing credit market by acquiring mortgages and issuing mortgage-backed securities. In 2025, it was ranked 50th on the Fortune Global 500 list, with revenues of $152.67 billion.