DePAI is gaining traction as a transformative force in the Web3 ecosystem by integrating blockchain technology with physical AI to enable autonomous machines. This innovative approach addresses challenges in coordination and value exchange through decentralized systems. Key projects such as Fetch.ai and Bittensor are at the forefront, developing the necessary infrastructure to support this evolution. A report from Web3Caff Research underscores the potential of blockchain technology to redefine machine economics. By offering a decentralized framework, DePAI facilitates new avenues for AI development and machine interaction, positioning itself as a potential trillion-dollar growth engine for the Web3 space.