In the rapidly evolving AI landscape, DeFi platforms face increasingly sophisticated hacking threats. A recent guide outlines a three-layer defense strategy to combat these attacks. The first layer focuses on surface attacks across protocols, contracts, and user boundaries. The second layer involves comprehensive mitigation strategies, including prevention, mitigation, pausing, recovery, and restoration. Key measures include using advanced AI for red team scanning, invariants and formal verification, multi-signature and guardian layers, whitelists/blacklists, and emergency mechanisms. The guide emphasizes the importance of continuous red teaming, strengthening exit limits, and enhancing governance and rescue capabilities to improve resilience against state-level threats. By implementing these strategies, DeFi platforms aim to bolster their defense mechanisms and ensure survival in the face of sophisticated cyber threats.