In 2025, decentralized finance (DeFi) is increasingly influenced by macroeconomic factors, with central bank policies, inflation, and currency fluctuations impacting on-chain markets. The DeFi ecosystem now mirrors global liquidity conditions, with yields and lending activities aligning closely with traditional financial markets. Stablecoins have become indicators of global economic stress, particularly in emerging markets like Argentina. DeFi's real-time transparency allows macroeconomic pressures to be visible and traceable on-chain. Innovations such as tokenized treasuries, restaking, and decentralized stablecoins are being explored to help DeFi reduce its dependency on macroeconomic conditions and evolve further.