Semler Scientific has increased its Bitcoin holdings by purchasing an additional 185 BTC for $20 million, bringing its total to 4,449 BTC valued at approximately $473 million. The US medical technology company has invested $410 million in Bitcoin since May 2024, achieving a book yield of 26.7%. Despite this, Semler's stock has fallen 37% this year, reflecting a mixed market response to its Bitcoin strategy. The company's ongoing Bitcoin acquisition is part of a broader trend among institutions, with approximately 3.4 million BTC held as reserves globally. While some companies have seen stock price gains from similar strategies, Semler's performance contrasts with others like Strategy and Japan's Metaplanets, which saw significant stock price increases in 2025. Bitcoin's price has been volatile, reaching a high of $112,000 but also dropping below $77,000 amid economic uncertainties.