Semler Scientific's Bitcoin asset valuation is closely aligned with its holding cost, as indicated by a net asset value multiple (mNAV) of 1.07. The company's enterprise value stands at $498.5 million, slightly surpassing its Bitcoin holdings valued at $466 million, which consist of 4,449 bitcoins. Matthew Sigel, head of digital asset research at VanEck, noted that similar pressures may affect other companies with significant Bitcoin reserves in upcoming quarters.